As part of their research, Karni and PhD student Maxim Mogilevsky designed a molecule that inhibits glioblastoma tumor growth by regulating the proteins it produces.
But now, researchers at the Hebrew University of Jerusalem, Israel have proposed a new treatment for glioblastoma – the type of cancer from which John McCain suffered – that has the potential to improve and lengthen patients’ lives.
The presence of visible fluorescence can serve as an intraoperative diagnostic surgical biomarker of high-grade glioma within a brain tumor, according to a study presented at the 2018 National Cancer Research Institute Cancer Conference, held from Nov. 4 to 6 in Glasgow, Scotland.
Liquid biopsies are fluid samples from patients, for example from the blood or urine, which provide a less invasive way to monitor disease compared to tumour biopsies. A less intrusive test could be hugely beneficial for brain tumours where collecting samples can be difficult and risky for patients.
Better treatments for medulloblastoma, ideally are sorely needed. But developing new cancer drugs is a time-consuming process, relying on multiple years of clinical research, followed by a minimum 10-month FDA approval process. Now, thanks to a new computational approach, the FDA’s extensive approval process could become a benefit for drug discovery instead of just a hurdle.
The results of the clinical trial found a 26 percent relative reduction in risk of cognitive toxicity following whole-brain radiation therapy with hippocampal avoidance versus whole brain radiotherapy. The cognitive function benefit of hippocampal avoidance did not differ by age.
A new use of stem cells has been identified that could clear a revolutionary pathway to making immunotherapy effective in brain cancer.
A new technique for “listening” may mean the difference between brain impairment and the retention of full cognitive capabilities following brain tumor removal.
A research team led by the University of Alabama at Birmingham is launching a study to find a better model for glioblastoma, a particularly devastating type of brain tumor, to help determine the most appropriate treatment modality. The $3.6 million, five-year U01 grant award is funded by the National Cancer Institute.
Researchers from Memorial Sloan Kettering Cancer Center (MSK) and Weill Cornell Medicine tested an approach that appears to be safe and effective at distributing a drug throughout diffuse intrinsic pontine gliomas (DIPG), a tumor that starts in the brain stem.
In children with diffuse midline glioma (DMG), liquid biopsy based on analyses of circulating tumor DNA (ctDNA) in cerebral spinal fluid (CSF) or plasma shows promise for detecting mutational load and may serve as tool for assessing tumor response to treatment, researchers say.
New research shows a specific protein regulates both the initiation of cancer spreading and the self-renewal of cancer cells in medulloblastoma, a type of pediatric brain cancer.
Dutch researchers have used augmented reality to help pinpoint brain tumors before surgically removing them. They found the technique was nearly as accurate as standard neuronavigation, and it has helped improve understanding of the anatomy and efficiency during a procedure.
Cells that protect newly generated neurons can be genetically engineered to activate anticancer drug, reduce tumor growth and improve survival in mouse model.
Glioblastoma and Melanoma metastasized to the brain are incredibly deadly brain cancers. However, pharmaceutical company Moleculin Biotech, Inc. hopes the diseases have met their match in a small molecule compound known as WP1066.
A researcher in San Antonio is trying to figure out if tweaking a medicine already used to treat the symptoms of glioblastoma could prolong lives. Andrew Brenner at the UT Health San Antonio MD Anderson Cancer Center has modified the drug Avastin, and is researching the effect.
Scientists have discovered a chemical compound that cuts off the “energy supply” to glioblastoma cells, making them self-destruct. Glioblastoma is a highly aggressive brain tumor.
A newly discovered chemical may improve brain cancer survival.
Researchers have successfully deployed a Zika virus vaccine to target and kill human glioblastoma brain cancer stem cells, which had been transplanted into mice. In a new study, the team shows that a live, attenuated version of the Zika virus could form the basis of a new treatment option for this fatal brain cancer.
Researchers at Duke have recently discovered a missing link that could be a breakthrough in treating glioblastoma—an aggressive form of brain cancer that doesn't respond to usual treatment. Part of the reason glioblastoma is so deadly is that patients with the disease have extremely low counts of T-cells—white blood cells that fight cancer.
Cancer-hunting stem cells developed from skin cells can track down and deliver a drug to destroy medulloblastoma cells that hide after surgery, according to results from early studies.
T-Cell immunotherapy is a multi-billion dollar success. Companies are genetically engineering an individual’s own immune cells to attack cancer in the blood or lymph system. Chimeric antigen receptor T-cell therapy, or CAR-T therapy has seen huge acquisitions and investments.
A multi-institution international team led by researchers at Baylor College of Medicine has developed a new strategy to overcome one of the main obstacles in the treatment of brain cancer – access to the tumor. Under the influence of cancer, the blood-brain barrier diverts immune T cells that attempt to enter the brain to fight the tumor.
5-ALA is approved for administration to patients to increase the detection of the margin of invading brain glioma tumors, and thereby allow for a wider or more extensive brain tumor removal. As the most important visualization tool in daily use for neurosurgery, operating microscopes are gaining advanced functionality with innovative illumination modes.
Neuro-Oncologist Sabine Mueller and her colleagues at UCSF are leading an effort that will sequence the genetic make-up of individual brain tumors looking for their unique traits. The goal is to find multiple ways to attack the tumor, using a cocktail of drugs.
The latest in a series of laboratory breakthroughs could lead to a more effective way to treat the most common brain cancer in children. Early studies demonstrate how cancer-hunting stem cells, developed from skin cells, can track down and deliver a drug to destroy medulloblastoma cells hiding after surgery.
Researchers are using machine learning to ease the harsh effects of treating glioblastoma, the form of brain cancer that took the life of Senator John McCain. The initiative underway at MIT offers hope for those patients suffering from the condition, as the new approach could reduce the toxicity of chemotherapy and radiotherapy.
A Saudi medical team has successfully used modern immunosuppressive therapy for a five year old Saudi girl with Glioblastoma, a grade 4 brain tumor known for being aggressive and very infiltrative. The new technology, according to the Saudi Press Agency, has successfully treated the girl without experiencing immunotherapy complications.
British researchers were experimenting with various chemicals that they hoped might slow down the growth of glioblastoma . To their surprise, one synthetic chemical called KHS101 did far more than expected, basically destroying the cancer cells completely.
Advances in medical science have resulted in higher cancer survival rates, but the treatments consisting mainly of chemotherapy and radiation are still rough on patients. A team of researchers from MIT has devised an AI platform that can help.
Researchers have tracked the missing T-cells in glioblastoma patients. They found them in abundance in the bone marrow, locked away and unable to function because of a process the brain stimulates in response to glioblastoma, to other tumors that metastasize in the brain and even to injury.
Acetazolamide, sold under the trade name Diamox, is a drug used to treat altitude sickness, glaucoma, epilepsy, heart failure, and seizures. According to a new study, acetazolamide may also be effective in treating the fast-growing brain tumor glioblastoma.
Theragen ETEX said Tuesday that it has developed a technique, which can identify the cause of recurrence of pediatric brain tumor, using genetic analysis technique.
The proof-of-concept technique allows biomarkers from a brain tumor to pass through the blood-brain barrier into a patient’s blood using noninvasive focused ultrasound and microbubbles. The focused ultrasound technique could be viewed as a tool for enhancing ‘two-way trafficking’ between the brain and blood.
Researchers have come up with a new drug-delivering nanoparticle which may provide a more effective means to treat the brain cancer glioblastoma. The particles are equipped to transport two different drugs.
Researchers have come up with a new drug-delivering nanoparticle which may provide a more effective means to treat the brain cancer glioblastoma. The particles are equipped to transport two different drugs.
A drug used to treat altitude sickness -- as well as glaucoma, epilepsy, heart failure and seizures -- may also offer significant gains for patients with a fast-growing brain tumor known as glioblastoma, according to a study published July 4, 2018, in the journal Science Translational Medicine.
Dr. Helen Dooley and other academics around the world, believe that proteins harvested from shark blood could be the key to diagnosing and treating diseases that are hard to target with existing drugs.
The poliovirus could help some patients battle a lethal form of brain cancer, scientists report. An experimental treatment seems to have prolonged the lives of a small group of patients with a type of brain cancer called glioblastoma, according to research from Duke University, published on Tuesday in The New England Journal of Medicine.
A new study led by scientists at VCU Massey Cancer Center has shown that an experimental drug known as AZ32 selectively sensitizes brain tumors to radiation and significantly extends the survival of mouse models with human glioblastoma multiforme (GBM).
Ataxia-telangiectasia mutated (ATM) protein orchestrates the cellular DNA damage response (DDR) to cytotoxic DNA double-strand breaks induced by ionizing radiation (IR). ATM genetic ablation or pharmacological inhibition results in tumor cell hypersensitivity to IR.
There’s been a groundbreaking find in the quest for a cure to an inoperable pediatric brain cancer. Diffuse intrinsic pontine glioma, or DIPG, has a survival rate of zero. However, a new trial has finally found a safe way to deliver drugs to the brain stem tumor using “convection-enhanced delivery.”
A Portuguese research team discovered a mechanism that controls the spread of glioblastoma, a form of malignant brain tumor, the Gulbenkian Institute of Science (IGC) said in a statement on Friday.
Glioblastoma is the deadliest form of brain cancer. Most patients survive about a year. But experimental treatments are helping some patients live longer, including one young father who's had promising results thanks to cutting edge treatments.
In an ongoing phase III clinical trial, a brain cancer vaccine has significantly prolonged the life of participants with glioblastoma.
A new multi-institutional project is studying cancer biology and care to identify why minority children have worse cancer outcomes compared to their white peers.
A research team , in collaboration with Prof. LIU Bin from the University of Singapore, reported the first NIR-II fluorescent molecule with aggregation-induced-emission (AIE) characteristics for dual fluorescence and photoacoustic imaging.
Glioblastoma multiforme is the commonest type of brain cancer, with "in-built" defense mechanisms that lend it resilience. Will new discoveries about the defenses help to eliminate this cancer more efficiently?
The results during the phase two clinical trial have doctors and patients excited. 91 percent are alive after 12 months, where normally we would only expect to see about 60, 61 percent make it that far. So it's had a phenomenal impact.
UVa researchers hope that focused ultrasound can provide a noninvasive solution to remove the growth — and that work might have been given a boost with a recent episode of “Grey’s Anatomy” that featured the technology.
Research project and trials may improve survival rates in dogs, and give other researchers more insight into glioblastoma to apply to human trials. "It turns out that dogs spontaneously develop these high-grade gliomas, these brain tumors that are very similar to the ones that people develop."
New Cleveland Clinic research shows for the first time that ibrutinib, an FDA-approved drug for lymphoma and leukemia, may also help treat the most common – and deadliest – type of brain tumor.
Researchers have simulated neural activity based on the unique structural architecture of individual brain tumor patients using a platform called The Virtual Brain. The findings, reported in eNeuro, are a first step toward creating personalized brain models that could be used to predict the effects of tumors and consequent surgery on brain function.
Removing cancerous tumors from the brain is delicate work, and one tool used by doctors at Intermountain Medical Center increases the chance of survival. A high -tech gamma knife gives doctors an extra edge when operating on head or brain tumors. The gamma knife allows doctors to finely focus X-ray beams to very specific spots in the brain and deliver a powerful dose of radiation to cancerous or even benign tumors.
Today, doctors are using advanced techniques to perform neurosurgeries, including the awake craniotomy, laser ablation and biomarkers to light up the tumor. Combine that with new immunotherapies, which use the patient’s own body to fight off the disease, and innovative targeted incisionless techniques, and there’s new hope for patients where it once looked bleak.
3D movies are known for making viewers feel like they’re in the middle of the action. The same type of technology is helping surgeons at Northwest Community Healthcare perform more precise surgeries.
Two genes play important roles for the formation of malignant cancer in the brain. One gene prevents the formation of the tumor, while another gene promotes the tumor. This is shown in a new dissertation at Umeå University, Sweden.
“Until the past decade, if you were diagnosed with a brain tumor and needed to get radiation therapy, you would get photon, or X-ray radiation,” Kahalley said. “Now, there is a newer technology called proton beam radiation therapy, which uses protons instead of photons.”
Doctors are using high tech tests to make sure life-saving surgeries are successful against a type of tumor that grows silently.Cynthia Sucher never imagined she’d be getting strapped into a safety harness where physical therapists would be measuring her reaction to being purposely moved off-kilter.
Glioblastoma, one of the deadliest forms of brain cancer, may have found its nemesis. New research shows that the tumor, which is notoriously difficult to treat, can be halted by an experimental compound.
The study noted a rise in glioblastoma cases in England from 983 in 1995 to 2,531 in 2015, which aligns with the rise of smartphones as a common tech device used by nearly everyone across the world.
Research on brain tumors, also called gliomas, addresses a critical piece of the puzzle for glioma development identified as a mutant gene. The discovery about gliomas will potentially allow researchers and physicians to understand them in much greater depth.
If the Zika virus can infect brain cells, can it infect and kill brain tumors? A small research team in Brazil found out that yes, it can, by killing cancer stem cells. Specifically, what they discovered was that a dose of purified Zika virus was able to shrink two types of brain tumors in 20 out of 29 treated mice.
Unlike many other tumors, ones found in the brain are usually too dangerous to take biopsies of. Now the researchers at Washington University School of Medicine in St. Louis came up with a revolutionary new way of using focused ultrasound to get tumors to release biomarkers that can then be spotted using blood samples.
80,000 new cases of primary brain tumors are expected to be diagnosed this year. Each of those will need the incredible expertise of a team of doctors and nurses in the operating room. But one hospital; is using a new team member. It's a new robotic camera now used at Florida Hospital in Orlando.
Toca 5 trial uses viral gene technology to target recurrent brain cancer is currently underway. The trial is being conducted at 67 sites across the United States, Canada, Israel and South Korea.
Researchers tracked genomic alterations detected in patient samples during tumor cell evolution in culture, in patient-derived xenograft (PDX) mouse models from the cultures, as well as before and after treatment in patients. The team reports that tumor progression was often driven by cancer-promoting genes, known as oncogenes, on extrachromosomal pieces of DNA.
“Brain tumors in dogs and humans are remarkably similar,” said Renee Chambers, professor in the Department of Neurosurgery at UAB School of Medicine. “They share similar rates of incidence and mortality, and they share similar symptoms such as seizures, which is often the first symptom observed in both humans and dogs. Treatment is very much the same too, with surgery, radiation and chemotherapy the standard of care.”
Researchers used an experimental molecular therapy in preclinical laboratory tests to effectively treat several types of deadly pediatric brain cancer and now propose advancing the treatment to clinical testing in children. The cancers include intrinsic pontine glioma (DIPG), high-grade glioma (HGG) and high-risk medulloblastoma (MB).
In mice, a fatal brainstem tumor was cleared by injecting it with engineered T cells that recognized the cancer and targeted it for destruction. The discovery is moving to human trials.
Specific biomarkers have been identified that could help assess the likelihood and severity of the recurrence of malignant glioma, a highly aggressive form of brain cancer, according to a study.
The Intraoperative MRI (iMRI) suite is a brand new tool at Dixie Regional Medical Center that’s changing the way brain surgery is performed. In this area, a metal door is all that separates brain surgery from MRI.
There have been promising results a drug approved for the treatment of pinworm showed when used in treating brain cancer. Encouraged by those results, another team of researchers turned to determining whether mesothelioma cells would also respond. Early study results show another parasitic drug could “effectively impair both mesothelioma cell growth and migration.”
Researchers have found an Achilles' heel for the most common form of malignant child brain tumors. By combining two kinds of medicines, it is possible to simultaneously attack the cancer cell’s division and its reinforcement system, which is necessary in order for treatment to be sufficiently effective.
The Brain Tumor Funders’ Collaborative works to identify potential therapies for patients with primary human brain tumors, with the goal of increasing progression-free patient survival and improving quality of life for patients affected by a primary brain tumor.
In a documentary titled: “Benefits for Humanity: From Space to Surgery” it explores the space robotics origins of Synaptive Medical’s robotic digital microscopes, Modus V and BrightMatter Drive. The video examines how technology has been adapted to healthcare and is now benefiting patients with brain cancer and spine diseases.
The addition of tumor-treating fields to maintenance temozolomide therapy extended survival among a cohort of patients with glioblastoma, according to results of a randomized phase 3 study. The regimen — in which a device attached to a patient’s scalp delivers continual doses of low-intensity electric fields — did not negatively affect patients’ quality of life, results showed.
Around the time the ketogenic diet was being developed, the work of a German biochemist named Otto Warburg began to uncover a potential application for this diet in the treatment of cancer. Warburg observed that cancer cells typically derive energy from different sources than healthy cells.
A single gene has been linked to an aggressive form of brain cancer, potentially paving the way for new therapies to treat the disease, according to research.
A new integrated 'omics analysis suggests that the transcription factor FOXM1 can act as a meningioma driver, prompting proliferation, progression, and relatively poor outcomes in individuals with the disease, a primary central nervous system tumor that forms in meninges tissue surrounding the brain and spinal cord.
Michigan State University scientists are testing a promising drug that may stop a gene associated with obesity from triggering breast and lung cancer, as well as prevent these cancers from growing.
The surgery looked like any other operation to remove a tumor. When doctors turned off the lights, however, parts of the patient’s chest started to glow. A spot over his heart shined purplish-pink. Another spot lit up in his lung.
Cholesterol may be required for medulloblastoma tumors to grow, study results showed. This finding suggests statins may be an effective therapy, according to researchers in the laboratory of Zeng-jie Yang, MD, PhD, associate professor in the cancer biology program at Fox Chase Cancer Center.
New ultrahigh field 7 Tesla Magnetic Resonance Imaging scanner — which uses a more powerful magnet to produce clearer images than standard scanners.
Young mice that received molecularly targeted therapies used to treat brain cancer in human patients sustained cognitive and behavioral deficits, but the deficits were largely reversible through environmental stimulation and physical exercise.
A new research effort by an international team of scientists reveals that machine-learning algorithms can be a powerful tool for medicine. The group managed to create and train an AI to successfully identify different types of brain tumors with impressive accuracy.
An international team of researchers has used methylation fingerprinting data as input to a machine-learning algorithm to identify different types of brain tumors. The team describes studying DNA methylation fingerprinting to create a system that is able to identify central nervous system (CNS) tumors and report on its accuracy.
While there are many types of radiation that are successful for cancer treatment, the benefit of using proton beams is that they target the treatment area without hitting other healthy areas, said Dr. Mitchell Machtay, chair of the UH department of radiation oncology.
There is some encouraging news in the battle against the deadliest form of brain cancer. It's an experimental drug that gets right to the tumor.
A new study by investigators finds that some types of glioblastoma tumors may be able to shed extracellular vesicles (EVs) - small packages of biomaterial - that can help to suppress the body's ability to mount an immune response against the tumor.
Called Tumor Treating Fields, the therapy was pioneered less than two decades ago by Israeli scientist Yoram Palti, who showed that when alternating electric fields are delivered at specific frequencies, they can disrupt the division of cancer cells and cause their death.
Investigators are seeking to determine whether the combination of eflornithine (alphadifluoromethylornithine) with lomustine can improve survival for patients with recurrent anaplastic astrocytoma (AA).
New research described how deep convolutional neural networks (CNNs) may improve MRI brain tumor segmentation. Computer engineering researchers proposed a high-capacity deep convolutional neural networks (DCNN) for the study.
Surgery, radiation and chemotherapy just don’t cut it against glioblastoma, a type of aggressive brain tumor with a dismal five-year survival rate. Survival is highest in younger people, at 19% for those aged 20 to 44, but it drops sharply with age, bottoming out at 5% for patients over 55. That’s why Gianpietro Dotti is working on an immunotherapy for glioblastoma.
Genetically engineered cancer-killing T-cells can hunt and attack brain tumors that display a new molecular target that is highly prevalent on brain cancer cells, report researchers.
Using tumor genome sequencing, researcher identified the first potential targeted drug to treat chordoid gliomas, a rare type of brain cancer that develops within the third ventricle, a fluid-filled pocket that helps cushion the brain.
Re-engineering a common cold virus to attack the deadliest kind of brain tumor extended the survival of patients whose tumor returned after various treatments, including surgery, a Phase 1 clinical trial shows. While patients with glioblastoma usually live a median of six months, half were still alive at 9/12 months after receiving the re-engineered virus. And 20 percent lived for three years or longer.
Nativis, a Seattle-based company developing a device that uses low-frequency radio energy waves to treat cancer and other diseases, announced Tuesday that its Voyager device is being considered for fast-track approval by the U.S. Food and Drug Administration.
Scientists just figured out how to shrink tumors using robots built from DNA strands. Their new technique was tested on breast, skin, ovary and lung cancers in both mice and pigs. It's a win because the robots can find and attack cancer cells, starving them of fresh blood supply, without hurting the rest of the body.
The collaboration of a chemical engineer who has done extensive computer modeling of biological and engineering systems a neurobiologist whose expertise is in cell motion and behavior in the brain, has produced a new and freely available computer program that predicts cancer cell motion and spread with high accuracy.
Researchers at Dartmouth's Norris Cotton Cancer Center, led by Damian A. Almiron Bonnin, MD-Ph.D. candidate of the Mark Israel laboratory, are devising strategies to prevent brain tumors from becoming resistant to anti-tumor drug treatment.
At age 7, Bella is seeing better results from a precise radiation called “proton beam therapy.”
“This type of radiation can go to the tumor, stop and then come back out,” said Josh, “whereas traditional radiation would pass through and then kinda bounce around.”
A common cold virus engineered to attack the most common and deadly of brain tumors allowed 20% of patients with recurrent glioblastoma to live for 3 years or longer, researchers from The University of Texas MD Anderson Cancer Center report on a phase I clinical trial in the Journal of Clinical Oncology.
Immune checkpoint inhibitors targeting the PD-1 pathway could be a promising approach in treating certain children with an aggressive form of brain cancer known as supratentorial pediatric ependymoma, researchers suggest. Pediatric ependymoma (EPN) is the third most common cancer of the central nervous system.
An undergraduate biochemistry student at Clemson University, approached his professor about wanting to start research on “some human stuff” in the spring of 2016, he didn’t imagine it would lead to the discovery of 22 genes that are implicated in glioblastoma, the most aggressive type of brain cancer.
Scientists have successfully uncovered a therapeutic approach that targets aggressive brain cancer stem cells and could lead to improved patient survival.
Researchers at Dartmouth's Norris Cotton Cancer Center, led by Damian A. Almiron Bonnin, MD-PhD candidate of the Mark Israel laboratory, are devising strategies to target glioma stem cells which could significantly improve patient survival.
Immunotherapy continues to prove its mettle in the fight against various forms adult cancers ranging from melanoma to lung cancer, to kidney cancer, and more. For instance, drugs that target immune checkpoint pathways, such as programmed cell death protein 1 (PD-1), help remove the genetic blindfold that cancer uses to hide from the immune system.
NBTS) today announced the launch of a new patient and care-partner education and preparedness effort. The new initiative will provide those going through the brain tumor medical experience with the information, tools, and guidance needed to play a more active role in their treatment planning and decisions.
Scientists have created a hair-thin implant that can drip medications deep into the brain by remote control and with pinpoint precision. Tested only in animals so far, if the device pans out it could mark a new approach to treating brain diseases — potentially reducing side effects by targeting only the hard-to-reach circuits that need care.
A diagnosis of the brain cancer glioblastoma carries a dismal prognosis. Now a team led by Massachusetts General Hospital investigators has found that adding the chemotherapy drug hydroxyurea to the current chemotherapy protocol for glioblastoma significantly increased survival in animal models.
The prognosis for all children diagnosed with an aggressive brain tumor known as DIPG and similar tumors has been mostly the same: dismal. But a small subset of patients with these tumors that bear mutations in a gene in the basic packaging of DNA may have better outcomes than others, suggests new research.
Researchers have discovered that killing cancer cells can actually have the unintended effect of fueling the proliferation of residual, living cancer cells, ultimately leading to aggressive tumor progression.
A drug that targets cancer cells’ ability to self destruct was recently cleared to be used in clinical trials for brain cancer patients. Patients with glioblastoma multiforme, an aggressive cancer of the brain, will be using this drug, PAC-1, with temozolomide, a traditional chemotherapy drug used as the standard form of treatment for brain tumors.
A unique clinical trial at the hospital and Georgia Cancer Center at Augusta University where Kaiden was one of the first kids with his kind of cancer to receive a homegrown therapy first discovered at Medical College of Georgia. The therapy is a drug called Indoximod that blocks an enzyme called indoleamine 2,3-dioxygenase or IDO for short.
Hyperspectral imaging, where data is captured over several contiguous narrow spectral bands, rather than the three distinct color bands of a conventional camera, is an attractive technique in medical treatment and diagnosis thanks to its non-contact and minimally invasive nature.
Biological clocks throughout the body play a major role in human health and performance, from sleep and energy use to how food is metabolized and even stroke severity. Now, Texas A&M University researchers found that circadian rhythms could hold the key to novel therapies for glioblastoma, the most prevalent type of brain cancer in adults—and one with a grim prognosis.
BXQ-350 combines a protein which is naturally expressed in humans, with nanobubbles of a fat molecule. This combination creates a treatment agent that has the ability to selectively target cancerous tumor cells and then kill them, largely sparing the surrounding healthy tissues.
A 27-year-old man has made a remarkable recovery from a first-of-its-kind brain tumor operation in Minnesota. Peter Carvalho underwent a three-hour operation less than a month ago in which a laser was used to heat up and destroy a brain tumor, which had caused depression and changes in his personality.
A little known pharmaceutical company in Florida has found itself in the eye of a storm following disclosures it raised the price of an old drug used to fight brain tumors by 1,400%, from US$50 a pill to more than $700. NextSource Biotechnology in 2013 bought the license for the drug Lomustine from Bristol-Myers Squibb.
Diffusion tensor imaging (DTI) may indicate prognosis among patients with brain metastases and the likelihood of their response to immunotherapy, according to a study published in Cancer Research.
It was announced today the initiation of a phase 1 study. The first patient has been treated in this open-label dose-escalation study to determine the safety and tolerability of the oral formulation of Basilea's novel anticancer drug candidate BAL101553 in combination with standard radiation in patients with newly-diagnosed glioblastoma.
The UW Health brain tumor program in Madison, Wisconsin, consists of a multidisciplinary team of neurosurgeons, radiation oncologists, medical neuro-oncologists, neuroradiologists, neuropathologists, neuro-otologists, pediatric neurologists, pediatric neuro-oncologists and pediatric neurosurgeons.
Man's best friend may help scientists learn more about a deadly brain cancer in people. Both dogs and humans can develop glioblastoma. Half of people diagnosed with this type of brain cancer live fewer than 14 months, even after treatment with surgery, radiation and chemotherapy.
A new study demonstrates that adding electric field therapy to chemotherapy can improve survival for those with glioblastoma, which is an aggressive brain cancer with few effective treatment options.
A device attached to a patient’s scalp that delivers a continuous dose of low-intensity electric fields can improve survival and slow the growth of a deadly brain tumor, a new clinical trial suggests. The new treatment for glioblastoma uses alternating electric currents called tumor-treating fields (TTFields), delivered through an array of insulated electrodes affixed to a patient’s shaved scalp.
A common medical test may help predict how long patients with cancer that has spread to the brain might survive and whether they are likely to respond to immunotherapy utilizing a novel MRI technique called Diffusion Tensor Imaging (DTI), which has the potential to remove the need for patients to undergo costly and dangerous biopsies.
According to research lead by the University of California San Francisco (UCSF), children with a deadly form of brain cancer might benefit from a new treatment that aims to direct an immune response against a mutated protein found exclusively on cancer cells.
The novel oncolytic virus Toca 511 (vocimagene amiretrorepvec) and Toca FC (extended-release 5-fluorocytosine [5-FC]) induced durable responses in patients with recurrent glioblastoma multiforme (GBM) and anaplastic astrocytoma (AA).
Doctors use a bioengineered protein that leaves healthy cells alone. It is called MDNA 55. "It can bind directly to tumor cells and bring in a payload, which is like a Trojan horse that acts directly on tumor cells and causes the tumor cells to undergo programmed cell death," said Achal Singh Achrol.
The U.S. Food and Drug Administration (FDA) has granted full approval for Genentech's Avastin (bevacizumab) for the treatment of adults with glioblastoma that progressed following prior therapy (referred to as recurrent disease).
An autopsy revealed something unexpected: Her bone tumors had melted away, leaving only a few cancer cells in her marrow.
The focus of the study, published online Dec. 4 in the Journal of Experimental Medicine, is diffuse intrinsic pontine glioma (DIPG), an aggressive pediatric brain cancer. DIPG is rare — estimates suggest that about 300 new cases occur in the United States each year — but almost always fatal.
Children with an extremely deadly form of brain cancer might benefit from a new treatment that aims to direct an immune response against an abnormally shaped protein found exclusively on cancer cells, according to a new study led by UC San Francisco researchers.
Glioblastoma is a type of very aggressive brain tumor. It's the same kind of tumor diagnosed in U.S. Sen. John Mccain.
About 12 to 15 percent of people with brain tumors have glioblastomas.
Previously, the authors of the study have shown that an experimental drug that inhibits polo-like kinase 4 (PLK4) stopped pediatric brain tumor growth in vitro. Now, they have demonstrated its success in an animal model - the drug shrank the tumor and increased survival.
A Boston biotech with a unique approach to treating an aggressive brain tumor, Ziopharm Oncology reported this weekend that its combination of experimental drugs has helped 15 patients survive about twice as long as they would have otherwise in an early-stage trial.
UC San Diego Health has expanded its treatment of rare brain tumors by launching a specialized program in the diagnosis and treatment of acoustic neuromas and complex skull base tumors.
The term “skull base” refers to the gap between the bottom of the brain and the part of the skull that is directly below it. Within the skull base are the blood vessels that supply the brain with nutrients and oxygen, as well as nerves that are critical to functions such as vision, smell, hearing, facial movement and breathing.
The newly-appointed head of the University of Minnesota Medical School’s neurosurgery department has unveiled encouraging early results from a research collaboration with a California biotech company seeking to treat aggressive and deadly brain cancer tumors.
A particularly aggressive form of pediatric cancer can be spotted reliably by the genetic fragments it leaves behind in children’s biofluids, opening the door to non-surgical biopsies and providing a way to gauge whether such tumors respond to treatment.
St. Jude Children's Research Hospital scientists have discovered a promising target for precision medicines to block a mechanism that drives several cancers, including about 30 percent of cases of the brain tumor called medulloblastoma.
A team from the Northwestern University Feinberg School of Medicine and the Translational Genomics Research Institute (TGen) have turned to ultra-low dosages of arsenic as a potential treatment against glioblastoma multiforme (GBM)—the most common and aggressive type of deadly brain tumor.
Bentley, a canine patient of Bush Veterinary Neurology Service (BVNS), has had a remarkable response to treatment of a glioma brain tumor. The treatment was performed through a clinical trial funded by the National Institutes of Health.
Doctors are now using a virus from a disease that's been largely eradicated to fight brain tumors.
The polio virus is the latest weapon in the fight against cancer.
Brain Tumor Research-funded Centre of Excellence, has secured funding from the Brain Research Trust, which will help to expose novel molecules and their modes of action responsible for the initiation and growth of the disease.
A team of researchers led by the University of Texas at Austin has developed a new, fully automatic method that combines biophysical models of tumor growth with machine learning algorithms to automatically identify brain tumors.
In a Yale School of Medicine laboratory, Pediatric Oncologist Dr. Juan Vasquez, is working hard at coming up with a vaccine to fight off brain tumors in children.
Study found that the drug combination tested in mice disrupts and exploits glucose intake, essentially cutting off the tumor's nutrients and energy supply. This treatment then stimulates cell death pathways which control the cancer cells' fate and prevents the glioblastoma from getting bigger.
A research group from the University of Texas at Austin’s Texas Advanced Computing Center presented results of a new, fully automatic method combining biophysical models of tumor growth with machine learning algorithms for the analysis of Magnetic Resonance (MR) imaging data of glioma patients.
As a neurosurgeon at Seattle Children’s Hospital, Dr. Amy Lee imagines a day when she’s removing an invasive brain tumor from a child while looking at a screen shining brilliant green, showing her precisely where the tumor ends and the healthy brain tissue begins.
The absence of a signaling molecule produced by the brain’s nerve cells stops the growth of certain brain tumors, according to a recent study by a group of researchers at Stanford’s School of Medicine.
New research out of MIT has made great strides into discovering the fundamental mechanisms behind this form of brain tumor. They have now found the reasons behind why glioblastomas grow so aggressively.
New research brings fresh hope of a new treatment for patients with glioblastoma, after identifying a way to halt the growth of this life-threatening brain tumor. Scientists have identified the mechanism by which a specific protein called PRMT5 drives the growth of glioblastoma tumors.
The researchers also identified a genetic marker that could be used to predict which patients would most likely benefit from this type of treatment. Glioblastoma is usually treated with radiation and the chemotherapy drug temozolamide, which may extend patients' lifespans but in most cases do not offer a cure.
MGMT promoter methylation status -- information gathered at a DNA-level -- can help predict overall survival for patients with a rare form of brain cancer known as anaplastic astrocytoma, according to a new analysis
The brain cancer diagnosis of glioblastoma has been in the headlines in the wake of Senator John McCain’s recent diagnosis the he describes as ‘very poor”. In this story we will go over the very basics of the 4 grades of brain tumors and the treatments available for them.
•Long-term results from a Phase 3 clinical trial, EF-14, assessing the addition of Novocure's (NVCR -0.7%) Optune to temozolomide in patients with newly diagnosed glioblastoma showed extended survival and improved quality of life.
Finding a cure is tough, but one promising trial at the UT Health Cancer Center is giving one local family hope.
New research conducted in mice provides evidence that highly lethal brain tumors, called high-grade gliomas, stop growing when deprived of a specific molecule naturally produced when brain cells fire.
Mayo Clinic Phoenix is using MRI scans and other pathology to create mathematical equations to tell them what a brain tumor is likely to do. Tumors, in a way, while they may seem to be unpredictable, actually follow a pattern
The largest genomic profiling study ever conducted into glioma brain tumors in children has identified genetic alterations in 96% of cases. As reported in The Oncologist, this genetic information could help to identify the most effective treatments for specific cases of glioma
The discovery of a mechanism by which normal brain cells regulate the expression of the NFIA gene, which is important for both normal brain development and brain tumor growth, might one day help improve therapies to treat brain tumors.
A study reports that the same biological qualities that let Zika do its devastating neurological fetal damage, can also destroy the stem cells of glioblastoma, the most common type of brain tumors.
The discovery of a mechanism by which normal brain cells regulate the expression of the NFIA gene, which is important for both normal brain development and brain tumor growth, might one day help improve therapies to treat brain tumors.
Cancer metastases to the brain are a major healthcare burden. For single metastases, surgical removal of the tumor followed by whole brain radiotherapy (WBRT) is the standard of care and has been shown to improve survival compared with WBRT alone. However, it may also decrease cognitive function.
A research team found that the Zika virus may selectively kill brain tumor cells while not harming normal brain cells...in a laboratory. The results are promising.
Researchers have discovered that the Zika virus can kill tumor cells from glioblastoma cancers. Here’s how it does that.
A study conducted by a researcher at São Paulo State University in Brazil, with support from the São Paulo Research Foundation (FAPESP), explores the mechanisms that make astrocytomas so aggressive and seeks ways to customize treatment to patient needs.
An experimental imaging tool that uses a targeted fluorescent dye successfully lit up the benign brain tumors of patients during removal surgery, allowing surgeons to identify tumor tissue shows.
Researchers at the Yale School of Medicine have used the CRISPR/Cas9 system — which allows researchers to alter the DNA sequence at specific points — to create a new and advanced mouse model for glioblastoma.
Researchers in Florida are using immunotherapy against two of the toughest medical problems: glioblastoma brain tumors and infections from sepsis and septic shock. Both conditions are deadly and fast-moving.
3D printed tumor models can help doctors and surgeons to get a better look at and understanding of the masses that they’re going to be treating or removing from a patient’s body, and they can also help patients to understand their own conditions.
Doctors Robert Fenstermaker and Michael Ciesielski have spent the last 20 years at Roswell Park, looking for ways to combat brain cancers.
"About 12 years ago, we started looking at a protein target called Survivin. It's expressed on tumor cells, it looked interesting, that this might be something we'd want to develop a vaccine to,” Ciesielski said.
The surgeons primarily created a computer model of the tumor to see where it is located and which parts of the brain it aligns to. The model became a navigation map for a computer system and a doctor.
There has been a lot of excitement recently surrounding the WP1122 technology and its potential to become a new approach for treating brain tumors.
A recently developed method of diagnosing 13 kinds of cancer from a single drop of blood can lead to early detection of the disease. The relatively inexpensive test puts less burden on patients, but it still needs further improvement in accuracy.
A Buffalo researcher and his research team have a potentially life saving therapy in the palm of their hands. They say they’re so close to getting a cancer fighting therapy on the market.
Neuroscientists have uncovered the genetic basis for why many long-term survivors of childhood cancer develop meningiomas, the most common adult brain tumour, decades after their treatment with cranial radiation.
Doctor trying a new technique called Magnetic Resonance Fingerprinting. It was developed at Case Western Reserve University in Cleveland. They have initial results from 25 children in a study.
In order for a cancer cell to enter the brain, it must first bind to the cells that line the structure separating the blood from the brain, which is called the blood-brain barrier (BBB). Such information about the factors associated with this process may provide a way of preventing the cancer cells binding to the BBB and crossing over into the brain.
Researchers in Roanoke are developing ways to halt the insidious onslaught of the type of brain tumor affecting Arizona Sen. John McCain.
New treatment bought brain tumor patient years of life
In April 2012, Phil enrolled in a clinical trial at M.D. Anderson Cancer Center in Houston. Doctors drilled a hole into his skull and injected his tumor with an altered form of the cold virus called Delta 24, designed to get the virus to consume the brain tumor, and, as viruses do, to make copies of itself that would eat more tumor.
U.S. Senator John McCain is battling glioblastoma. These tumors had been difficult to remove because the cells dig in deep into the brain, and the fingers of the cells extend out centimeters away from the tumor. Doctors couldn’t see them, until recently with the drug Gliolan or 5 ALA, that turns the cancer cells pink has been approved by the FDA.
For patients, like Sen. John McCain (R-Ariz.), who develop aggressive brain cancer, the first-line treatment is almost always radiation and chemotherapy. But if the glioblastoma recurs, and it almost always does, what then?
New research has identified a key mechanism that allows cancerous growths to proliferate, or multiply, in the brain. This has led scientists to develop a new drug that could be used to inhibit malignant cells.
The new treatment, called Intra-Arterial Chemotherapy, or IAC, delivers chemotherapy through the femoral artery in the leg, then through the body, and into the brain, where the chemotherapy is released in blood vessels directly feeding the site of tumor.
The Hippocratic Oath advises doctors to first DO NO HARM … so imagine intentionally using a virus that causes paralysis in hopes of treating the deadliest form of brain cancer.
Researchers have identified a unique metabolic signature associated with epileptic brain tissue that causes seizures. The chemical biomarker can be detected noninvasively using technology based on magnetic resonance imaging.
Patient benefits by a new piece of equipment, a “positioning board” that allows for even more precise targeting of tumors, as part of radiation therapy in the Gainesville-based Northeast Georgia Health System.
Experimental Brain Cancer Therapy Harnesses Stem Cells, Cold Virus
A phase 1 clinical trial is exploring an investigational neural stem cell therapy for the treatment of brain cancer. This approach combines stem cell therapy with a common cold virus and has been observed to target and kill aggressive brain cancer cells, according to a press release from Northwestern Medicine.
Early phase Northwestern Medicine research has demonstrated a potential new therapeutic strategy for treating deadly glioblastoma brain tumors. The strategy involves using lipid polymer-based nanoparticles to deliver molecules to the tumors, where the molecules shut down key cancer drivers called brain tumor-initiating cells (BTICs).
The team has developed cancer-killing viruses that can deliver stem cells via the carotid artery, and applied them to metastatic tumors in the brains of clinically relevant mouse models.
Scientists reveal, for the first time, the role of the cellular prion protein in the development of neurofibromatosis 2 tumors -- with potential impact on other cancers, too
Experimental treatment provides hope against brain tumor
Researchers have developed a new method to screen brain tumor cells and identify potential drug targets missed by traditional methods finding a new drug target in glioblastoma that, when inhibited, significantly extended survival in preclinical mouse models.
New research has identified a specific change in the body’s immune system that may be a predictor of the most common cancerous brain tumors ― gliomas ― five years before an individual develops symptoms.
A therapy based on a discovery there nearly 20 years ago is offering him and others a better quality of life and hope for the future.
Between 8 and 18 percent of people who have cancer also have diabetes. A strong link exists between diabetes and different types of cancer.
There may be new hope in extending the lives of patients with GBM. Researchers from The University of Texas Southwestern Medical Center in Dallas have tested a new approach that has proven to destroy GBM in mice. The study was recently published in Nature Neuroscience.
Immune Cells Deliver Cancer Drugs to the Brain
By harnessing neutrophils, a critical player in the innate immune response, scientists have devised a way to deliver drugs to kill these residual cells, according to a mouse study published today (June 19) in Nature Nanotechnology.