The use of proton radiotherapy to treat the most common malignant brain tumor in children is as effective as standard photon (x-ray) radiation therapy while causing fewer long-term side effects such as hearing loss and cognitive disorders.
As more and more health care institutions consider the viability of providing proton therapy to their patients, new research has emerged to further cement the notion that, where young lives are concerned, there is no better option currently available.
A powerful, three-way mechanism by which a mutation drives the growth of childhood brain cancers, was discovered by scientists. The team hopes the discovery will lead to better methods for diagnosing and treating these cancers, which cannot always be cured with surgery.
While mapping vessels in tumours has proven a challenge, researchers have now developed a combined MRI and ultramicroscopy 'toolkit' to study vessel growth in glioma models in more detail than previously possible.
Proton radiation is more "precisely focused" than photon radiation, which lessens the chance healthy tissue surrounding the target area will be affected.
When comparing numbers regarding IQ loss over extended periods of time, PBRT showed a decline of 0.7 IQ points per year while the traditional photon radiation treatment was marked at 1.1 points per year.
A comprehensive analysis of the molecular characteristics of explains why some patients diagnosed with slow-growing (low-grade) tumors quickly succumb to the disease while others with more aggressive (high-grade) tumors survive for many years.
Thanks to advances in science, however, there’s now a handheld microscope that can look at the brain on a cellular level while inside the operating room, and allow surgeons to decide more confidently where to stop cutting.
A new study may explain why some patients diagnosed with slow-growing, low-grade tumors end up quickly succumbing to the disease while others with supposedly more aggressive high-grade tumors survive for many years.
A local brain cancer specialist believes more lives could be saved if doctors took a closer look at individual tumors, which is the game-changing approach that saved one teen in Agoura Hills.
The iMRI is a unique set-up that melds the sterile environment of an operating room with the imaging technology of an MRI machine. It allows neurosurgeons the ability to scan patients during surgery and see a detailed image of their progress in real time.
The idea was to find a way to model all the mutations of a particular glioblastoma simultaneously, with the goal of using data from real tumors to find targets that can be effectively attacked.
The iMRI allows neurosurgeons to fully evaluate brain imaging during surgery and to image a patient while in the operating room, which allows a surgeon to ‘see’ if all the cancer has been removed before leaving the OR.
Gleostine® 5 mg capsules has been approved by the FDA . It is approved for use as a single agent treatment or with other approved chemotherapeutic agents to treat both primary and metastatic brain tumors.
"As a truly minimally invasive surgery, I anticipate that the quality of life of the laser-treated patients to be significantly improved relative to conventional surgeries where large incisions are made and significant portions of skull are removed."
While most high school students look forward to spending their summer vacations catching up on some well-deserved rest, one Cotter senior spent two weeks of his summer working on computer coding software that would aid surgeons operating on patients with brain tumors.
Dr. Tsung says, "It allows us to scan the patient as we're operating - to define what we're taking out, how much we removed, and to protect critical areas of the brain… The patient remains sterile, the brain remains open as we run into the scanner and we roll them back out."
Scientists have identified a protein interaction that is a hallmark of an aggressive subtype of medulloblastoma and that may provide a new treatment strategy. The research appears today in the scientific journal Cancer Cell.
Stem cells found in the tumors are responsible for making glioblastoma hard to treat because they are drug-resistant and self-renewing. This study is the first to focus on how the extracellular matrix surrounding the tumor affects the development of cancer stem-like cells in a 3D microenvironment.
Cells, when dividing, utilize and enzyme called Dicer. This helps cells repair any DNA damage that occurs when errors are made as cells copy genetic material again and again. Scientists have used this knowledge as a new technique to kill rapidly dividing, cancerous cells in the brain.
For patients undergoing surgery for low-grade glioma, who must be "awake" to facilitate mapping, hypnosis allows surgeons to safely remove the tumor up to functional boundaries, according to a first-of-its-kind study.
Scientists at the Salk Institute have discovered a key to how glioblastoma multiformetumor cells proliferate so quickly --and ways to turn this engine of tumor growth into a target for cancer treatment. The late Senator Ted Kennedy succumbed to this disease in just over a year.
An international research team has shown for the first time that a specific enzyme is responsible for sensing the available supply of GTP, an energy source that fuels the uncontrolled growth of cancer cells. The research underscores the enzyme’s potential to become a therapeutic target for future cancer drugs.
A technique which replaces general anesthetics was used on 37 patients undergoing surgery to remove brain tumors. Though there's been little science to back up hypnotherapy, the authors conclude that their small study's success suggests hypnosis could be a viable tool to help sedate patients during delicate brain surgery.
Progression-free and overall survival were prolonged with maintenance therapy involving tumor-treating fields (TTFields) and chemotherapy in patients with a brain tumor who had completed standard chemoradiation, according to early research findings published in JAMA.
A noninvasive, low-cost blood test was developed to help doctors diagnose some types of malignant childhood tumor Cancer. The test could enable clinicians to monitor treatment effectiveness without exposing patients to repeated doses of radiation.
The surgeons behind the study believe that this research proves that “hypnosedation” can be a valuable tool for patients with advanced brain cancers.
Patients receive injections – directly at the tumor site – of immune cells genetically modified to recognize certain markers on cancer cells.
A study of gliomas found that DNA structure was disrupted, allowing separate segments to merge and activate a growth gene. An existing chemotherapy drug may fix that.
Scientists say they have developed a novel 3D cell culture technique that allows brain tumor growth to be studied directly and without the need for complex experiments using live animals.
An electromagnetic field therapy known as tumor-treating fields could extend the lives of patients with a brain tumor when combined with routine chemotherapy, according to early research.
An MRI contrast agent that can pass through the blood-brain barrier will allow doctors to detect deadly brain tumors called gliomas earlier. This ability opens the door to make this fatal cancer treatable.
Cell biologists are taking clues from marching ants, flocking birds and other animals to learn how groups of cells move through the body. Such studies are yielding insights about cell movement during development as well as the spread of cancer.
Experimental drugs that alter cell metabolism also halted tumor growth and extended survival in mice with cancers linked to changes in the same gene, according to a new study.
Former President Jimmy Carter announced that recent brain scans found no evidence of cancer. After being diagnosed with melanoma, a very serious type of cancer affecting his liver and brain, he credited Keytruda, a new cancer drug, for shrinking his brain tumors entirely.
Researchers at the University of Basel took a close look at a signaling pathway present in most organisms and found that it suppresses the formation of specific types of brain tumor.
In a development that promises to aid vascular & brain tumor surgeons, University of Arizona bioengineers have developed a novel microscope that combines 2 images of tissue in a single view – the optical image overlaid with a fluorescence image from dye attached to tiny structures in cells.
3D printed medical models help both doctors and patients prepare for complex surgeries by providing exact replicas of patients’ body parts. With a consideration for the patients’ comfort-levels central, the Netherlands’ Radboud University Medical Center has been working on an alternative to the usual MRI or CT scans used to diagnose and treat brain tumors.
A new clinical trial in which cancer patients are given a chemotherapy drug delivered directly into their tumors is giving hope to people with a highly aggressive type of brain cancer.
The vaccine, Rintega, which was designed to enable the immune system to recognize and fight against glioblastoma multiforme, was shown to improve the survival rate of patients who were given the vaccine along with Avastin by up to two years compared to patients who were just given Avastin.
A research team at Okayama University and Kinki University developed a boron-based compound (BSH) that accumulates in malignant cells rather than in healthy cells, which can be used in radiation therapy.
Berkeley Lab researchers develop nanoparticles that can carry therapeutics across the brain blood barrier - the network of blood vessels that allows essential nutrients to enter the brain but blocks the passage of other substances.
Dr. Vogelbaum from the Cleveland Clinic and his team are studying a new tool that helps get chemotherapy past the brain's protective barrier, directly into brain tumors. The device is called a multi-port catheter and doctors are able to deliver medication through tiny tubes directly into the brain tumor.
Cancer drug developer GenSpera has reported encouraging results from phase II studies of its lead candidate mipsagargin on treating brain cancer - results showed the tolerability and indications of effectiveness of mipsagargin in advanced brain cancer patients.
Surgeons in the Neuroscience Institute at Allegheny General Hospital are now using laser energy and MRI visualization to remove brain tumors that previously were difficult to access via other minimally-invasive surgical techniques.
"The radiation therapy fields now are much more precise, similar to a sniper. It becomes very important that we don’t cause any collateral damage because the bullet we’re using is a lot more powerful, but if it’s misdirected, it can cause a lot more damage.”
For the first time, doctors have breached the human brain's protective layer to deliver cancer-fighting drugs. The Canadian team used tiny gas-filled bubbles, injected into the bloodstream of a patient, to punch temporary holes in the blood-brain barrier.
A new treatment option at Baptist MD Anderson Cancer Center could help extend the life of newly diagnosed brain tumor patients. Patients diagnosed with glioblastoma multiforme now have an additional tool that works along with chemotherapy and radiation.
Canada’s medical researchers have found a breakthrough method to deliver chemotherapy drugs using a new ultrasound technique to breach the brain’s protective membrane and sneak past the stubborn blood-brain barrier.
The preliminary success of this research opens the door for treatment of other brain diseases that are normally hindered by the protection of the blood-brain barrier, including brain tumors, Alzheimer's disease, and many psychiatric conditions.
In a significant breakthrough, the Translational Genomics Research Institute (TGen) has identified a drug, propentofylline or PPF, that could help treat patients with deadly brain cancer.
Scientists have pioneered research evidencing the use of cerebrospinal fluid (CSF) as liquid biopsy for the potential prognosis, treatment, identification and tracking of brain tumor genomic alterations not only in real time but over time.
A team of Canadian scientists has done something completely extraordinary and has permeated the blood-brain barrier (BBB) inside of a living patient to administer chemotherapy medication.
Laser Ablation - the process enables surgeons to destroy brain tumors and lesions with pinpoint precision and allows patients to avoid conventional invasive surgery.
Scientists at Toronto’s Sunnybrook Hospital have taken the next bold step in chemotherapy by developing a non-invasive procedure to treat brain tumours.
Gamma Knife Perfexion, a technology that has been referred to as the “gold standard” treatment for non-invasive radiosurgery of the brain.
The first trial failed to reduce her tumor, but in January 2014, Rooney was enrolled in a second trial that shrunk her tumor from the size of a half dollar to dime size.
The time taken to diagnose brain tumours in children in this country has been slashed thanks to new guidelines from the University of Nottingham. The guidelines and a national awareness campaign have taken the UK from one of the worst ranking countries in the world to one of the best.
thromboDx, a molecular diagnostic company announced that a 283 subject study shows that its' blood platelet based diagnostic platform enables accurate detection, classification and subtyping of cancer in the equivalent of one drop of blood.
Federal health officials on Tuesday approved a first-of-a-kind drug that uses the herpes virus to infiltrate and destroy deadly skin cancer tumors.
Research is underway at Washington University to test a new approach to cancer treatment. Beyond traditional therapies like surgery, chemotherapy and radiation, scientists want to know if the human body's own immune system can attack tumors.
A new microscope, developed in the University's Medical School, could help surgeons with the difficult task of tumor removal by showing the difference between healthy and tumorous tissue in real-time.
Research into life-extending treatments for brain cancer patients has been taking a rare turn toward the hopeful, as trials of immunotherapy and tumor treating fields (TTF) are showing promise of beneficial results. - See more at: http://www.clinicaloncology.com/ViewArticle.aspx?d=Solid+Tumors&d_id=148&i=October+2015&i_id=1236&a_id=34003#sthash.MtNvMWjy.dpuf
Danish scientists at the University of Copenhagen and the University of British Columbia may have accidentally stumbled on to a discovery that could possibly be a game changer in the fight against cancer.
When Avi Yaron found out he had an inoperable brain tumor, he didn't take it lying down. Rather than accept that his life was over, he invented the technology that saved his life and is now saving the lives of thousands of others around the world.
But a new laser-based microscopic technology may help surgeons see the difference between tumor tissue and normal brain in real-time.
An imaging technology called MR spectroscopy is allowing doctors to diagnose brain tumors without putting patients through the rigors of a brain biopsy.
With more than 100 types of cancer, glioblastoma is one of the more aggressive forms of brain cancer, which can shorten life spans anywhere from two weeks to two years. To add months to a patient's life, doctors are trying a new treatment called Optune.
The U.S. Food and Drug Administration today approved an expanded indication for the Optune device to treat patients with newly-diagnosed glioblastoma multiforme (GBM), an aggressive form of brain cancer.
The Optune device uses NovoCure’s “tumor treating fields,” which use low-intensity, intermediate-frequency alternating electric fields that limit cancer cell replication and kill cancer cells.
A rabbit virus currently being developed for cancer therapy can be paired with one of several existing drugs to deliver a more potent punch to a deadly type of brain tumor cell, researchers have found.
The Optune device delivers low-intensity alternating electric fields to the brain. The procedure is disrupting cell division and killing cancer cells.
Scientists found that combining anticoagulant drugs and antidepressants can cause cancer cells to eat themselves and hinder the progression of the killer disease.
EPFL scientists have found that combining antidepressants with anticoagulants slows down brain tumors (gliomas) in mice.
OncoRx Pharmaceuticals, Inc. is announcing its launch as an early-stage pharmaceutical company focused on the development of drug therapies that control the progression of therapy-resistant malignant tumors.
Scientists and neurosurgeons are working together to build a huge bank of pediatric brain tumor samples to advance research and find cures.
A new article published in Neurology suggests that being overweight or obese may be linked to an increased risk of developing meningioma, a type of brain tumor.
Current drugs may stop working against the most common type of brain tumor in children, medulloblastoma, but the tumor could be targeted in a new way, according to Stanford University scientists.
In research to be published in the journal eLife, a team tested a drug in mice with a brain tumor that is resistant to Vismodegib, the drug in current use. The drug, normally used to treat inflammatory lung diseases, dramatically inhibited tumor growth from the first day of treatment.
An associate professor of epidemiology at the Ohio State University led a research that found changes in the immune function five years before patients were being diagnosed with glioblastoma.
A young Chicago Bears fan who named his brain tumor after Aaron Rodgers will get to attend the season opener against the Green Bay Packers on Sept. 13
NASA scientists are working with researchers at the Skull Base Institute in Los Angeles to develop a “super instrument,” an endoscope with a 3D camera that will allow neurosurgeons to better navigate brain tissue during tumor resections.
The first group of patients has completed their initial dose of a special nanotechnology delivery of radioactive fat particles that target cancer cells in the brain, leaving the healthy tissue mostly untouched.
A new treatment for glioblastoma could enter clinical trials following the results of a new mouse study that looked at the effects of chemotherapy agent decitabine combined with T cell immunotherapy.
Investigators have discovered that determining the tumor's subgroup can be achieved noninvasively, using magnetic resonance spectroscopy (MRS).
UCLA scientists have developed a potentially promising new combination therapy for glioblastoma, the most common and deadliest form of brain cancer.
A new laser-based tool would allow surgeons to tell cancer tissue from normal brain tissue at the microscopic level while they are operating and would avoid the problem of leaving behind cells that could spawn a new tumor.
A brain tumor is not always the death sentence many people think it is. "We have good techniques and it's not as dire as people think. From a neurosurgery standpoint, we have gotten pretty good at managing these patients with our arsenal of therapies and advances."
During an operation to remove a brain tumor for the first time in Europe, the researchers used the non-invasive technique, which measures light reflected off tissue to determine whether it is cancerous or healthy.
A young man has successfully undergone pioneering brain surgery. The procedure used two technologies - a laser probe and a smart knife - that appear set to revolutionize the performance of delicate surgery.
A study highlighting high-grade gliomas in children which found better survival rates with gross total resection (GTR), specifically in girls.
Doctors are treating former president Jimmy Carter's metastatic melanoma with a Keytruda, a combination of the latest immunotherapy drug and advanced radiation. It was just approved by the Food and Drug Administration last year and is the first of its kind.
A brain tumor patient was chosen to participate in an experimental treatment. She has to wear a head wrap for 24-hours a day. "It's supposed to send radio waves or something electrical to your brain that I can't feel, but it's supposed to keeping the tumors from growing," the patient said.
epidermal growth factor receptors (EGFR) promote tumor progression in many types of cancer.
Scientists at The University of Texas MD Anderson Cancer Center have shown that EGFR (epidermal growth factor receptors) may be shut down with the help of a cytokine known as MIF (macrophage migration inhibitory factor). It’s a finding they believe could signal a new way to look at treating tumors.
The doctors at the University Medical Center Utrecht asked Ambroz Bajec-Lapajne to sing in order to monitor his ability to vocalize and recognize the key change during the brain tumor surgery.
Drugs called ion channel blockers might prove useful in cancer therapy, according to research findings in fruit flies and mice by UC San Francisco scientists that led to unconventional treatment of a case of metastatic brain cancer.
Drugs called ion channel blockers, which are commonly used to treat cardiac, neurological, and psychiatric disorders, might prove useful in cancer therapy.
The experiments revealed that glioblastomas, described by medical experts as highly invasive brain tumors, take longer to spread when communication between the cells that comprise them is shut down.
The molecular makeup of brain tumors can be used to sort patients with gliomas into five categories, each with different clinical features and outcomes, researchers have shown. The finding could change the methods that physicians rely on to determine prognosis and treatment options.
Two Chemical Compounds Have Been Found Effective In Slowing Brain Cancer Cells