Researchers at the Perelman School of Medicine at the University of Pennsylvania (Philadelphia, PA) have developed a fluorescence imaging tool that makes tumors glow brightly during surgery. In a new study, the fluorescence method illuminated brain tumors in real time during surgery, helping physicians distinguish between healthy and cancerous tissue.
A study identified alterations in a protein known as ATRX in human brain tumors that arise as part of a genetically inherited condition known as neurofibromatosis type 1 (NF1). The disorder, marked initially by benign tumors on nerves, often leads to brain cancer, and although most NF1-related malignancies are nonaggressive, a fraction are "high-grade" and difficult to treat, experts say.
Two recently discovered genetic differences between brain cancer cells and normal tissue cells -- an altered gene and a snippet of noncoding genetic material -- could offer clues to tumor behavior and potential new targets for therapy, Johns Hopkins scientists report.
Scientists, however, are still seeking more effective medications with fewer side effects. If they succeed in their efforts to better target blood vessels, patients will be able to live with cancer, just as HIV patients now live with the virus.
Optune is another option that is now available at the Cancer Center at St. Vincent Anderson Regional Hospital. The Food and Drug Administration-approved device looks like a white cap but is actually four adhesive patches, called transducer arrays, that are placed on the scalp.
Cancer is the most common cause of death in South East Asia which can easily be eradicated by preventing measures, early diagnosis and proper treatment including surgical, safe radiation and chemotherapy. Patients at M. Hashim Memorial are treated with Gamma Knife and X-Knife Stereotactic Radiosurgery, which is only the fifth machine in the world and only one in Pakistan.
Using state-of-the-art molecular biology and statistical approaches, researchers have identified the functional role of two distinct DNA modifications in glioblastoma tissues. The signature of one of these pattern disruptions in particular, 5hmC, had a particularly strong association with patient survival.
Glioblastoma is the most common and most severe form of brain cancer. Of the 12,000 new cases diagnosed each year, 10,000 patients will die in about a year. But a new vaccine developed by researchers in Buffalo, New York, is showing promising results.
Optune’s tumor-treating fields (TTFs) offer an entirely new type of treatment. Unlike chemo, this electrical treatment doesn’t cause collateral damage in other parts of the body.
In research findings , a team of researchers and a neurosurgeon invented a targeted way to overcome chemotherapy drug resistance and destroy the deadliest brain tumors while sparing surrounding brain tissue.
Researchers at The University of Texas MD Anderson Cancer Center have identified a pathway by which cancer cells aggressively spread and grow in the brain, opening up new possibilities for treatment.
An experimental cancer imaging tool that makes tumors glow brightly during surgery has shown promise again in a new clinical study, this time in patients with brain cancer.
Next-generation sequencing for patients at UCSF Medical Center is prompting changes in brain tumor diagnoses for some children and a retooling of treatment plans in many cases.
A published study reveals that a protein called RSK2 is increased in many patients with glioblastoma. The protein pushes glioblastoma cells into surrounding healthy brain tissue. The invasion of these cells throughout the brain makes it difficult to remove the tumor by surgery
Researchers have identified genetic mutations in this form of brain cancer that can distinguish aggressive rhabdoid meningiomas from more benign forms using routine laboratory tests. The new findings could have immediate implications for clinical decision-making.
Through a collaborative study, researchers examined the effects of a new inhibitor of PPARα in glioblastoma.
An early-phase clinical trial at Cleveland Clinic is investigating the use of an engineered virus to treat brain tumors. So far, the therapy is showing some signs of success.
The new treatment uses a live virus, which is injected directly into the brain tumor. The virus carries a special gene which makes the tumor more sensitive to a specific medication.
Researchers have identified a potential new treatment for brain cancer by learning from a rare condition that can cause microcephaly, which is a condition in which infants are born with an abnormally small head.
Researchers at Huntsman Cancer Institute (HCI) at the University of Utah report they have identified an existing group of drugs that appear to reduce or eliminate a certain subgroup of childhood brain cancers while sparing normal brain tissue.
Scientists around the world are using the latest research methods to look for new approaches to DIPG treatment.
Aggressive brain tumors call for aggressive treatment. Unfortunately, it’s not always enough. New research reveals a brand new treatment may provide the key to help physicians contain the most common and deadly types of brain tumor.
Sciences have identified potential drugs for treating brain cancer in children. In a study published in the journal Cell Reports, the research team says their potential new treatments reduce or eliminate a subgroup of childhood brain cancers while leaving brain tissue intact.
Study identifies potential treatments for children's brain cancer.
Administering immune cells derived from a cancer patient’s own blood may be a promising treatment approach for glioblastoma, providing 50 percent higher progression-free survival rates than the current standard of care.
Using MR spectroscopy, researchers at UT Southwestern Medical Center have found a new biomarker, 2HG, to track certain tumors that occur in the brain.
Brain Tumor Cells Will Shrink, Die Without Cholesterol, Study Finds
UT Southwestern Medical Center researchers have developed an MRI-based method that can track the state and progression of a common type of genetically mutated brain cancer.
A Ludwig Institute for Cancer Research study has identified a metabolic vulnerability in the aggressive and incurable brain cancer glioblastoma (GBM) and shown how it can potentially be exploited for therapy
The study demonstrates that GBM cells import vast amounts of cholesterol to survive and that the mechanisms they use to do so can be specifically and effectively undermined with drug-like molecules currently in clinical development.
Using an experimental bio-paint, scientists have gained the ability to watch a brain tumor glow. Using this improved visual ability this will make surgical procedures more accurate.
Novocure announced today that the first patient has been enrolled in the METIS trial, a phase 3 pivotal trial studying radiosurgery plus Tumor Treating Fields (TTFields) compared to radiosurgery alone for the treatment of brain metastases from non-small cell lung cancer.
A high response rate with a single drug in a phase I/II trial of pediatric brain tumor has set the stage for combination therapy with higher response and lower toxicity, researchers report.
A device has been developed for quick, accurate identification of a mutation strongly associated with a cancer that affects the central nervous system, potentially enabling accurate removal of the entire tumor during an operation.
Optune, a device using an array of strategically placed electrodes on the head, interrupts the cycle of cancer cells.
Lasers can be used to remove large, "inoperable" brain tumors, including glioblastoma, with the help of a "mini" craniotomy, according to a new study conducted by University Hospitals Cleveland Medical Center.
In the phase I trial, study participants who received the targeted experimental treatment survived 14 months compared to about seven months among those who did not receive the drug. For some patients, survival was extended to more than two years.
Stereotactic radiosurgery (SRS) for cancer patients who receive the treatment for brain metastases decreases the likelihood of local recurrence but shows no positive difference in terms of overall survival (OS) or distant brain metastases (DBMs) rates.
A Yale Cancer Center team revealed that the addition of chemotherapy to postoperative treatment for adults with medulloblastoma improves survival. The benefit of chemotherapy, in addition to craniospinal radiation, was seen in adult patients with medulloblastoma (MB), including those with localized disease who received high-dose radiation treatment following surgery.
Researchers at the University of Bonn have now developed a completely new method as the basis for creating custom-tailored, two-stage therapies. Using tumor samples from a patient, they do lab tests to determine which substances can first make the different types of cancer cells uniform and then effectively kill them.
A potential way of stopping one of the most aggressive types of brain tumor from spreading has now been identified by researchers, which could lead the way to better patient survival. They are fast growing and can spread easily. The tumor has threadlike tendrils that extend into other parts of the brain making it difficult to remove it all.
Performing brain surgery on patients who are awake allows surgeons to map — and preserve — areas of the brain that are vital to a patient’s functioning.
Doctors recommended a high-tech laser surgery. "It's a small incision, probably about the length of my fingernail, in the scalp," said Dr. Eric Leuthardt. "A small hole in the skull about the size of a pencil, and then this laser probe gets placed into the center of the tumor.”
For doctors, it can be difficult to tell the difference between brain cells killed by cancer treatment and recurrent brain cancer using patient's MRI scans. Computers, however, appear to be far more accurate. An algorithm was nearly twice as accurate as doctors at distinguishing between dead cells and recurrent cancer.
The program was nearly twice as accurate as two neuroradiologists in determining whether abnormal tissue seen on magnetic resonance images (MRI) were dead brain cells caused by radiation, called radiation necrosis, or if brain cancer had returned.
New study suggests that whole brain radiotherapy doesn’t do much good, if at all, when it comes to treating secondary brain tumors in lung cancer patients. In fact, it may only extend a sufferer’s lifespan by less than a week’s time, with numerous side effects kicking in as a result.
Thanks to wonders such as laparoscopy, robotic solutions, and, more recently, the iKnife and the laser probe, surgical intervention is getting safer all the time.
A case report suggests that a calorie restricted ketogenic diet can help treat cancers like brain cancer.
Initial findings from clinical trials separately exploring the safety and efficacy of immunotherapy agents nivolumab (Opdivo) and pembrolizumab (Keytruda) as potential treatments for patients with glioblastoma are promising.
The vaccine, SurVaxM, is considered a ‘next generation’ treatment for brain cancer using immunotherapy. Dr. Robert Fenstermaker, chair of Neurosurgery at Roswell Park has teamed with Ph.D. researcher Michael Ciesielski in creating the vaccine designed to stimulate a patient’s own immune system to essentially hunt down tumor cells and kill them.
The phase-one study involves injecting a virus directly into a patient's brain. "What this does is it infects the cell and turns it into a factory to create more virus. That then spreads within the tumor,"
Intraoperative MRI (ioMRI) soon may be must-have technology for many if not most neurosurgical suites, but those looking to take the plunge for their brain-tumor service line should expect longer procedure times and more scrupulous pre-operative room preparation.
Previous research had suggested that whole brain radiotherapy could cause difficulties with short-term memory and slow speech in patients.
Researchers determined that patients who got the precise brain radiotherapy experienced less cognitive decline — and less impairment to their quality of life.
When five craniotomies failed to permanently remove the mass, surgeons didn’t know if he would live— much less go on to perform a highly technical sport that requires physical strength and coordination. But after undergoing multiple rounds of laser ablation therapy, an emerging surgical technique for removing pediatric brain tumors that he finished in early June, Gavin is like a regular kid again.
As for the impact of advanced imaging, Linsler et al. point out that CT and MR help clinicians formulate a “better preoperative surgical strategy” that can result in “better surgical outcomes and an improved postoperative resection control, impacting the progression-free survival time
Chemotherapy in clinical trials is designed to kill cells by aiming at specific targets, such as damaging DNA; causing leakage of cancer cell membranes; inhibiting new protein synthesis; interfering with essential cell functions, or blocking cells from dividing and growing.
A new Tel Aviv University study reveals a novel way of detecting brain micrometastases months before they transform into malignant inoperable growths. According to the research, micro-tumor cells hijack astrogliosis, the brain's natural response to damage or injury, to support metastatic growth. This knowledge may lead to the detection of brain cancer in its first stages and permit early intervention.
A new scientific study has characterized a checkpoint protein that allows certain brain tumor cells to avoid the immune system. Tumors regularly avoid detection by decorating themselves with proteins that mimic those found on healthy cells.
The effects of ketogenic diets are not limited to seizure prevention. Ketogenic diets have shown beneficial effects and are being studied as therapeutic options for an impressively high range of neurological disorders.
Researchers at the Salk Institute have discovered a crucial key to how these tumor cells proliferate so fast and also how to use the finding into a target for cancer treatment. The details of the study finding were published recently in the journal Science Advances.
Computer-guided intra-operative brain mapping, proton beam radiation therapy and breakthroughs in immunotherapy among advances to be discussed
Pablo received devastating news at age 25: He had a terminal brain tumor and only between 6 and 9 months to live. He was given no hope of a cure. After studying online, Pablo chose to implement a ketogenic diet instead. Two years later, he’s still miraculously alive and the tumor is apparently not even growing.
Brain tumors are one of the rare forms of cancers but can be deadly if left untreated. A new discovery has led to the promising cure of brain tumors with the use of Aspirin in its liquid form.
The three-year study showed for the first time that a dendritic cell vaccine in combination with the antibody blockade of an immune cell surface receptor known as PD-1, generates a more effective immune response against glioblastoma than the use of either treatment alone.
New research at Washington University School of Medicine in St. Louis provides clues to why some patients with glioblastoma fare worse and identifies a drug target that potentially could improve survival.
Researchers at Yale University have developed a new method to quantitatively screen cell migration responses of glioma cells to platelet-derived growth factor (PDGF).
A new breakthrough in brain cancer research has shed light on how fatal brain tumors grow and has introduced a new drug target for treatment of the disease. Findings suggest that instead of growing through sugar consumption, glioma – a type of malignant brain tumor – are fueled by fats.
Researchers at the University of North Carolina are working to perfect stem-cell research after a discovery made regarding glioblastoma. The research team has found that surgically removing these brain tumors causes cancer to grow 75 percent faster than before surgery.
The basic scientific consensus surrounding glioma, the most common form of fatal brain tumor that affects every four in 100,000 people, is that sugars fuel its growth. However, a new study from Newcastle University shows that fats are its primary energy source.
New treatments are urgently needed, and in a study published in eLife, the team shows that targeting just one protein has two effects, it both halts the division of the cancer cells, and stops these cells from spreading through normal tissue, a two-in-one approach.
Using an engineered protein, researchers think they can direct chemotherapy to hard-to-reach and treatment-resistant tumors that could help reduce symptoms of the treatment while increasing its efficacy ... killing cancer while not harming surrounding healthy cells.
One of the biggest problems with brain cancer treatment is that only a limited amount of chemotherapy drugs make it through. A team of French scientists have recently tested a promising answer to that issue: an ultrasound implant that they designed to temporarily make this "blood-brain barrier" permeable.
In a surprising twist, benign brain tumors that have previously been tied to obesity and diabetes are less likely to emerge in those with high blood sugar, new research has found.
The cells lining blood vessels in the brain form tight, tough-to-penetrate junctions that prevent toxic molecules from slipping into the brain.
Unfortunately, this blood-brain barrier also blocks cancer drugs from reaching tumor cells in the brain.
When it comes to battling a particularly aggressive form of brain tumor, more extensive surgeries may be best to boost patient survival, researchers have concluded. The brain cancer -- called glioblastoma multiforme -- is often treated with surgery, radiation therapy and chemotherapy.
Brain cancer patients might benefit from an implantable ultrasound device that appears to enhance chemotherapy treatment, a small study says. Researchers tested the experimental device on 15 patients with recurrent glioblastoma, a particularly deadly brain cancer.
A new study suggests that blocking an enzyme called PRMT5 in tumor cells could be a promising new strategy for the treatment of glioblastoma (GB), the most aggressive and lethal form of brain cancer.
Advanced medications are available to treat the brain tumors. Increasing pharmaceutical R&D spending is expected to provide the lucrative growth for the global brain tumor treatment market over the forecasted period.
Johns Hopkins Medicine researchers report they have developed an experimental laboratory test that accurately clocks the “speed” of human brain tumor cell movement along a small glass “track.”
It seems like brains have finally appeared on the 3D printing radar. Just two weeks ago, Scottish researchers revealed that they were using 3D printed brain tumor replicas to push cancer research, and now researchers from Aston University are going even further.
Post Graduate Medical Institute Principal and Lahore General Hospital Prof Khalid Mahmood has said that a modern method of operation through nose has been introduced for removing brain tumor.
New data at the American Society of Clinical Oncology annual conference in Chicago took a look at how liquid biopsies could influence how we treat cancer. These tests rely on something called "circulating tumor DNA", or the bits of DNA that are released from dying tumor cells into the bloodstream.
The clinical evaluation of various anti-GD 2 monoclonal antibodies in children with neuroblastoma has been exclusively focused on treatment of patients after recovery from consolidation, in a state of ‘minimal residual disease’. This is because traditionally chemotherapy has been thought to be too immunosuppressive to combine with monoclonal antibodies.
The Heriot-Watt team will 3D print brain tumour (glioma) stem cells and other types of cells isolated from patients’ brain tumors, to recreate tumor-like constructs which should give much closer results to human tumors and reduce the current dependence on animal testing.
Researchers have developed an experimental brain cancer treatment that uses a tumor-killing virus called Toca 511 to destroy cancer cells. A new study has uncovered an experimental brain cancer treatment that might successfully extend the lives of patients two-fold using a virus.
Now, a new treatment shows promise. It uses stem cells grown from the skin and placed into a bandage-like material created at N.C. State University. That material is then put into the brain following surgery to remove a tumor. The stem cells will crawl and find the main tumor but also crawl and find all those little invasive fingers and roots that are so hard to get.
In a small clinical trial with brain cancer patients, a tumor-seeking virus successfully invaded cancer cells and smuggled in molecular detonators, allowing doctors to selectively blast the deadly growths with a toxic drug. The virus-drug combo nearly doubled their average survival time while showing no dangerous side effects.
According to new study conducted by US federal on rats, mobile phone radiation did increase rats' brain tumors in males. It raises concerns as smartphone is being used so much by so many people on a daily basis and they are always carried along with each person during the day.
The gamma knife treatment for brain tumors, available at HCA Virginia’s Johnston-Willis Hospital in Chesterfield County, is revolutionary for some patients. But that help is restricted to patients whose tumor is small — smaller than 3 centimeters. Otherwise, courses of action are widely different.
The study targeted rodents that were given doses of radiation every day for two years. Results produced were released on Friday that showed many male and female rodents developed brain and heart tumor after the experiment.
“Both the House and Senate have now spoken on the importance of expanding federal research into brain cancer,” said Elizabeth WILSon, president and CEO, American Brain Tumor Association. “We are grateful to Senator Ed Markey (D-MA) for making this request, and we also thank the Senate Appropriations Committee for listening to our community and including this in their annual defense spending bill.”
A new Neurology study investigated genes in the immune system and identified eight immune genes that may be linked to patients’ length of survival after developing the cancer.
A study using nanotechnology to treat brain tumors got such good results, the researchers initially questioned themselves. But further testing showed the results held up.
Researchers at the University of Miami, Florida International University and Nichols Children's studying ways to pierce the blood-brain barrier to treat brain tumors.
Proton beam therapy works differently from conventional radiation treatments, which rely on X-rays. Birusingh was the first patient to undergo the treatment— which uses a three-story, 200,000 pound machine— at the hospital.
Researchers have studied possible causes behind the development of brain tumors. The results show differences in expression of certain molecules known as metabolites when comparing healthy individuals with people who would eventually develop brain tumors. The greatest difference were found when looking at vitamin E.
The process would use a re-engineered polio virus, injecting it directly into the brain. The polio attacked the tumor, first causing it to swell, then awakening the immune system to attack the tumor.
National Brain Tumor Society dedicated to the brain tumor community, together with Oligo Nation, a community-driven non-profit dedicated to funding translational oligodendroglioma research, today announced $250,000 in grant-funding for a preclinical research study of an immunotherapeutic approach to oligodendroglioma treatment.
Researchers have shown previously that the therapeutic ketogenic diet (KD) prolongs survival in mouse models of glioma, explained by both direct tumor growth inhibition and suppression of pro-inflammatory microenvironment conditions. The aim of this study is to assess the effects of the KD on the glioma reactive immune response.
A team from the International School for Advanced Studies (SISSA) in Trieste has obtained very promising results by applying gene therapy to glioblastoma. Tests in vitro and in vivo on mice provided very clear-cut results, and modelling demonstrates that the treatment targets at least six different points of tumour metabolism.
A bold experiment to kill a vicious form of brain cancer has been granted breakthrough status by the Food and Drug Administration. Results in the earliest stage of testing have been so remarkable, the FDA wants to fast track the treatment to speed it to market.
The electrodes, battery pack and knit cap are the outward signs of Ledesma’s treatment. Attached to his head are 36 ceramic electrodes, which are attached to a battery pack that emits electrical impulses.
New technologies have been developed to improve the efficacy of treating a wider range of tumors, especially in delicate locations like the brain. The progressive cancer care and imaging center was among the first to deliver an emerging form of advanced radiation therapy called stereotactic radiosurgery (SRS). Now known as the Veterinary Radiosurgery and Imaging Center (VRIC), the leading-edge practice is part of a national network of cancer care centers operated by PetCure Oncology.
The blood-brain barrier is a natural defense system that prevents harmful substances in the blood from entering the brain. Doctors may have found a way to get past the barrier to treat cancer patients which may allow them to deliver chemotherapy drugs directly into the brain.
Scientists have used sophisticated pharmacologic modeling and simulation to translate preclinical findings into a successful phase I clinical trial of a chemotherapy agent for treatment of ependymoma. The research marked the first time the approach has been used to calculate drug doses for a clinical trial in pediatric brain tumor patients.
We’ve heard it a gazillion times that cell phone use can cause tumor in brain. But fret not all you mobile phone users out there, there is no link between mobile phone use and brain cancer, reveals a new, long-running study.
Removing every last cancer cell or killing them all with radiation is at best a hit-and-miss solution. Fewer than 10% of those who are afflicted with gliomas live five years. Therefore, news from scientists in Belgium working with mice and using cancer vaccines against gliomas is encouraging, if not remarkable.
The fight against deadly forms of brain cancer, such as glioblastoma, could soon benefit from a major breakthrough, thanks to A*STAR researchers. The team has found a new link between cancer cell growth and its microenvironment.
Neurosurgeons using lasers to treat brain cancer have discovered that the technique breaks down the blood-brain barrier. The blood-brain barrier is sort of a natural "security system" that shields the brain from toxins in the blood but also blocks potentially helpful drugs such as those used in chemotherapy.
Oncurious in Leuven (Belgium) was launched as an emerging oncology company focused orphan drugs for the treatment of pediatric cancers. Its current candidate is preparing for a phase I/IIa trial for the treatment of relapsed or refractory medulloblastoma – a rare, life-threatening brain tumor that mainly affects children.
Glioblastoma tumors were successfully infiltrated by investigational chimeric antigen receptor (CAR) therapy with an acceptable safety profile, according to phase 1 study results presented at the American Association for Cancer Research 2016 Annual Meeting.
A leading medical device company in the field of nanomedicine focused on oncology, today announced that Vivantes Friedrichshain, Department of Neurosurgery has initiated Commercial NanoTherm(TM) Treatments for brain cancer.
Optune is an FDA-approved portable, noninvasive device that delivers Tumor Treating Fields (TTFields) therapy to patients with newly diagnosed and recurrent glioblastoma.
A key player in brain tumor formation has been found that may lead to new therapies for a deadly and incurable cancer. The study is the first to show that a protein called OSMR (Oncostatin M Receptor) is required for glioblastoma tumours to form.
Immunotherapy represents an exciting advance in cancer treatment that harnesses the immune system to seek and destroy cancer cells.
In the study, researchers found that people who regularly took aspirin had a nearly 34 percent lower risk of a type of brain tumor called a glioma, compared with people who didn't take aspirin regularly.
Immune cells engineered to seek out and attack a type of deadly brain cancer known as glioblastoma (GBM) were found to have an acceptable safety profile and successfully migrate to and infiltrate tumors researchers reported.
Research demonstrated a significant enough link between children having acquired chickenpox and their reduced likelihood of developing brain cancer that the results shouldn’t be dismissed as coincidence.
University of Florida experts examined mice models of human glioblastoma and discovered that a high-fat, low carbohydrate diet can help to stall the development of tumor cells and increase lifespans by 50 percent.
It is more like a sensor that surgeons can run over tissue matter and supposedly in half a second, it will be able to tell the surgeon which part of the tissue is tumorous and which part isn’t, so like we said, it helps reduce the rate of errors.
Be prepared for goosebumps!
If you want to see more on this, watch this 10:39 video on this amazing relationship between player and patient.
Scientists discovered a compound in blue-green algae called coibamide A
It cuts off cancer cells' communication with blood vessels and other cells.
They studied 251 patients -- half of whom underwent radiation treatments only, half underwent both radiation and chemotherapy treatments. The researchers learned that those who received both treatments lived an average of 5 1/2 years longer, and many are doing well 10 years later.
A new test can help doctors pinpoint what is driving the tumor and better target their treatment early on. This time, doctors took a small sample of his tumor and ran it through cutting-edge molecular testing designed to pick up genetic mutations. It’s called Glio Seq.
Much cancer research is focused on immunotherapy rather than chemotherapy for treatment. Immunotherapy stimulates the body’s own immune system to fight a malignancy and has numerous advantages over chemotherapy.
Removing a brain tumor is a delicate task, if not done properly it can have catastrophic consequences, such as brain damage, motor impairment or failure in controlling a vital organ function. In order to make this work more precise, a "smart scalpel" that determines whether an area is healthy or tumorous.
The study shows that in glioblastoma (GBM), the essential amino acids methionine and tryptophan are abnormally metabolized due to the loss of key enzymes in GBM cells.
When doctors detect a tumor the next course of action is typically surgery, but when it's a brain tumor, surgery isn't always an option. So what can you do? Well doctors at Avera will soon be able to take the cutting out of brain surgery.
Diffusion Pharmaceuticals Inc. CEO David Kalergis. lays out Diffusion’s plan for pivotal development of its treatment for primary brain cancer.
Medical team experimented with MRI techniques to track “natural killer” cells after they were injected with fluorine-19, a non-radioactive, naturally occurring isotope.
Doctor believes with an as-yet-to-be-determined combination of immunotherapy and precision medicine, brain cancer researchers may finally make some headway against this long intractable problem.
A next-generation immunotherapy may offer hope for treating high-grade glioma. While dendritic cell-based immunotherapy is known to be promising, this study combined dendritic cell immunotherapy with immunogenic cell death.
When doctors diagnosed a 4-year-old doctor with brain tumors, they told her parents there was little hope. But then they all decided to take the only chance they had. 3 ago, no one knew if Allison would ever walk to the bus stop. Now, it's hard keeping up with her.
What if before initiating treatment, they could go a step further and use a mini-model of the human body to see how each patient's actual tumor responds to the drugs and learn if and where the tumor is likely to spread?
A cap fitted with arrays of electrodes and worn on the head all day and all night, Optune uses alternating electric fields to disrupt the tumor in the vital process of cell division. If the cells don't divide, the tumor doesn't grow.
Scientists at Memorial Sloan Kettering Cancer Center’s Kircher laboratory have developed a biomarker that adsorbs exclusively to the surface of cancerous cells in brain tumors. The technology can be used for therapeutic purposes (surgery) as well as diagnostics, even in the early stages of cancer.
Researchers have identified a new combination therapy for the most aggressive form of medulloblastoma, a fast growing type of pediatric brain cancer.
Scientists at the nonprofit Translational Genomics Research Institute (TGen) have identified a drug called propentofylline, or PPF, that could help patients suffering from glioblastoma multiforme (GBM), a deadly form of brain cancer.
Opdivo is a new class of medicine called an immune-oncology drug. What’s unique about the drug, and as many as 100 more in pharmaceutical pipelines that are expected to work in similar ways, is how they fight cancer cells.
Researchers believe they may have found a way to turn a patient’s skin cells into cancer killing cells, leading to a “groundbreaking discovery” for brain cancer patients.
Stem cells from a patient’s own skin may help fight the most common and most aggressive forms of brain cancer, according to University of North Carolina at Chapel Hill researchers who tested the theory in a lab.
Jimmy Carter announced that his doctors are stopping his immunotherapy treatment called pembrolizumab after they saw no signs of tumors over a period of three months.
Elekta announced that its Leksell Gamma Knife® Icon™, the most precise stereotactic radiosurgery (SRS) system currently available, was used for the first time in the US on 3/1 at Sutter Medical Center to treat a metastatic brain tumor.
Moffitt Cancer Center researchers recently reported that expression of the protein BIRC3 is associated with poor survival and recurrent disease in GBM patients; and therefore may be a good therapeutic target.
Clinical outcomes were similar with the Gamma Knife Perfexion (Elekta AB) and RapidArc (Varian Medical Systems), a linear accelerator (LINAC)-based volumetric modulated arc therapy (VMAT).
Scientists from KU Leuven in Belgium say they have shown that next-generation cell-based immunotherapy may offer new hope in the fight against brain cancer.
Children with brain cancer may soon get some help from mice with the same disease. In a new paper in Science Translational Medicine, the U-M team describes how they developed a novel brain tumor model in mice.
USC School of Pharmacy researchers who led the study on mice found that the drugs stifle the growth of brain cancer, glioma or glioblastoma, by suppressing the enzyme “monoamine oxidase A,” which affects the release of emotional brain chemicals.
Early stages of testing a vaccine that targets EGFRvIII — a genetic abnormality of the epidermal growth factor receptor (EGFR) that occurs in about one-third of glioblastoma patients and that’s associated with tumor growth and resistance to therapy.
Antidepressants can shrink and stunt cancerous brain tumors that are otherwise difficult to treat, an international team of researchers has found.
Gamma Knife and RapidArc offer different strengths, they are equally effective at eradicating cancer in the brain. The Gamma Knife was slightly more effective than RapidArc at focusing the beam of radiation and RapidArc offered much quicker treatment.
VBL Therapeutics is moving to the final stage of clinical trials for its leading product, VB-111, for the treatment of brain tumor patients. The trial will compare VBL's drug used in combination with oncological drug Avastin with the use of Avastin by itself in the treatment of recurring glioblastoma.
Virtual reality is becoming increasingly useful when it comes to the medical field. Physicians used a VR headset to map a patient's brain during surgery to remove a tumor late last month.
Two small structural elements, called decorin and lumican, could be decisive in the development of a resistance to the drugs currently used for treating glioblastoma multiforme, such as temozolamide.
A team of researchers have identified a common molecular alteration in glioblastoma. They observed that the cells of this type of tumor harbor a common intrinsic defect that prevents them from degrading their genetic material during apoptosis, the most important form of programmed cell death induced by radiotherapy and chemotherapy.
The low-carb, high-fat ketogenic diet can replace chemotherapy and radiation for even the deadliest of cancers, said Dr. Thomas Seyfried, a leading cancer researcher and professor at Boston College.
A new two-drug combination, currently in use in the clinical trials, might help people diagnosed with glioblastoma to fight the disease. The researchers are using a combination of drugs to disrupt the cellular process cancer cells use to hide from the immune system.
Despite the letdown of prior research, the future looks bright for immunotherapeutics and novel targeted therapy approaches for patients with gliomas.
The use of proton radiotherapy to treat the most common malignant brain tumor in children is as effective as standard photon (x-ray) radiation therapy while causing fewer long-term side effects such as hearing loss and cognitive disorders.
As more and more health care institutions consider the viability of providing proton therapy to their patients, new research has emerged to further cement the notion that, where young lives are concerned, there is no better option currently available.
A powerful, three-way mechanism by which a mutation drives the growth of childhood brain cancers, was discovered by scientists. The team hopes the discovery will lead to better methods for diagnosing and treating these cancers, which cannot always be cured with surgery.
While mapping vessels in tumours has proven a challenge, researchers have now developed a combined MRI and ultramicroscopy 'toolkit' to study vessel growth in glioma models in more detail than previously possible.
Proton radiation is more "precisely focused" than photon radiation, which lessens the chance healthy tissue surrounding the target area will be affected.
When comparing numbers regarding IQ loss over extended periods of time, PBRT showed a decline of 0.7 IQ points per year while the traditional photon radiation treatment was marked at 1.1 points per year.
A comprehensive analysis of the molecular characteristics of explains why some patients diagnosed with slow-growing (low-grade) tumors quickly succumb to the disease while others with more aggressive (high-grade) tumors survive for many years.
Thanks to advances in science, however, there’s now a handheld microscope that can look at the brain on a cellular level while inside the operating room, and allow surgeons to decide more confidently where to stop cutting.
A new study may explain why some patients diagnosed with slow-growing, low-grade tumors end up quickly succumbing to the disease while others with supposedly more aggressive high-grade tumors survive for many years.
A local brain cancer specialist believes more lives could be saved if doctors took a closer look at individual tumors, which is the game-changing approach that saved one teen in Agoura Hills.
The iMRI is a unique set-up that melds the sterile environment of an operating room with the imaging technology of an MRI machine. It allows neurosurgeons the ability to scan patients during surgery and see a detailed image of their progress in real time.
The idea was to find a way to model all the mutations of a particular glioblastoma simultaneously, with the goal of using data from real tumors to find targets that can be effectively attacked.
The iMRI allows neurosurgeons to fully evaluate brain imaging during surgery and to image a patient while in the operating room, which allows a surgeon to ‘see’ if all the cancer has been removed before leaving the OR.
Gleostine® 5 mg capsules has been approved by the FDA . It is approved for use as a single agent treatment or with other approved chemotherapeutic agents to treat both primary and metastatic brain tumors.
"As a truly minimally invasive surgery, I anticipate that the quality of life of the laser-treated patients to be significantly improved relative to conventional surgeries where large incisions are made and significant portions of skull are removed."
While most high school students look forward to spending their summer vacations catching up on some well-deserved rest, one Cotter senior spent two weeks of his summer working on computer coding software that would aid surgeons operating on patients with brain tumors.
Dr. Tsung says, "It allows us to scan the patient as we're operating - to define what we're taking out, how much we removed, and to protect critical areas of the brain… The patient remains sterile, the brain remains open as we run into the scanner and we roll them back out."
Scientists have identified a protein interaction that is a hallmark of an aggressive subtype of medulloblastoma and that may provide a new treatment strategy. The research appears today in the scientific journal Cancer Cell.
Stem cells found in the tumors are responsible for making glioblastoma hard to treat because they are drug-resistant and self-renewing. This study is the first to focus on how the extracellular matrix surrounding the tumor affects the development of cancer stem-like cells in a 3D microenvironment.
Cells, when dividing, utilize and enzyme called Dicer. This helps cells repair any DNA damage that occurs when errors are made as cells copy genetic material again and again. Scientists have used this knowledge as a new technique to kill rapidly dividing, cancerous cells in the brain.
For patients undergoing surgery for low-grade glioma, who must be "awake" to facilitate mapping, hypnosis allows surgeons to safely remove the tumor up to functional boundaries, according to a first-of-its-kind study.
Scientists at the Salk Institute have discovered a key to how glioblastoma multiformetumor cells proliferate so quickly --and ways to turn this engine of tumor growth into a target for cancer treatment. The late Senator Ted Kennedy succumbed to this disease in just over a year.
An international research team has shown for the first time that a specific enzyme is responsible for sensing the available supply of GTP, an energy source that fuels the uncontrolled growth of cancer cells. The research underscores the enzyme’s potential to become a therapeutic target for future cancer drugs.
A technique which replaces general anesthetics was used on 37 patients undergoing surgery to remove brain tumors. Though there's been little science to back up hypnotherapy, the authors conclude that their small study's success suggests hypnosis could be a viable tool to help sedate patients during delicate brain surgery.
Progression-free and overall survival were prolonged with maintenance therapy involving tumor-treating fields (TTFields) and chemotherapy in patients with a brain tumor who had completed standard chemoradiation, according to early research findings published in JAMA.
A noninvasive, low-cost blood test was developed to help doctors diagnose some types of malignant childhood tumor Cancer. The test could enable clinicians to monitor treatment effectiveness without exposing patients to repeated doses of radiation.
The surgeons behind the study believe that this research proves that “hypnosedation” can be a valuable tool for patients with advanced brain cancers.
Patients receive injections – directly at the tumor site – of immune cells genetically modified to recognize certain markers on cancer cells.
A study of gliomas found that DNA structure was disrupted, allowing separate segments to merge and activate a growth gene. An existing chemotherapy drug may fix that.
Scientists say they have developed a novel 3D cell culture technique that allows brain tumor growth to be studied directly and without the need for complex experiments using live animals.
An electromagnetic field therapy known as tumor-treating fields could extend the lives of patients with a brain tumor when combined with routine chemotherapy, according to early research.
An MRI contrast agent that can pass through the blood-brain barrier will allow doctors to detect deadly brain tumors called gliomas earlier. This ability opens the door to make this fatal cancer treatable.
Cell biologists are taking clues from marching ants, flocking birds and other animals to learn how groups of cells move through the body. Such studies are yielding insights about cell movement during development as well as the spread of cancer.
Experimental drugs that alter cell metabolism also halted tumor growth and extended survival in mice with cancers linked to changes in the same gene, according to a new study.
Former President Jimmy Carter announced that recent brain scans found no evidence of cancer. After being diagnosed with melanoma, a very serious type of cancer affecting his liver and brain, he credited Keytruda, a new cancer drug, for shrinking his brain tumors entirely.
Researchers at the University of Basel took a close look at a signaling pathway present in most organisms and found that it suppresses the formation of specific types of brain tumor.
In a development that promises to aid vascular & brain tumor surgeons, University of Arizona bioengineers have developed a novel microscope that combines 2 images of tissue in a single view – the optical image overlaid with a fluorescence image from dye attached to tiny structures in cells.
3D printed medical models help both doctors and patients prepare for complex surgeries by providing exact replicas of patients’ body parts. With a consideration for the patients’ comfort-levels central, the Netherlands’ Radboud University Medical Center has been working on an alternative to the usual MRI or CT scans used to diagnose and treat brain tumors.
A new clinical trial in which cancer patients are given a chemotherapy drug delivered directly into their tumors is giving hope to people with a highly aggressive type of brain cancer.
The vaccine, Rintega, which was designed to enable the immune system to recognize and fight against glioblastoma multiforme, was shown to improve the survival rate of patients who were given the vaccine along with Avastin by up to two years compared to patients who were just given Avastin.
A research team at Okayama University and Kinki University developed a boron-based compound (BSH) that accumulates in malignant cells rather than in healthy cells, which can be used in radiation therapy.
Berkeley Lab researchers develop nanoparticles that can carry therapeutics across the brain blood barrier - the network of blood vessels that allows essential nutrients to enter the brain but blocks the passage of other substances.